It is structurally complex and has a number of different functions such as immunological monitoring of bloodborne antigens, storage of blood and destruction of aged or abnormal blood cells. Pdf the spleen is the largest secondary immune organ in the body and is responsible for initiating immune reactions to bloodborne antigens and for. Surgical anatomy of the human spleen wiley online library ireland. In this article, we are sharing with our audience the genuine pdf download of inderbir singhs human embryology 11th edition pdf using direct links which can be found at the end of this blog post. Histology is the study of the microanatomy of cells, tissues, and organs as seen through a microscope.
Anatomy, embryology, histology and physiology of the spleen. Histology of the spleen 101 wealth of knowledge about the structure and function of the different compartments in the rodent spleen. The sinuses are lined by elongated, rodshaped endothelial cells. Spleen histology spleen, dog labels histology slide. I am extremely thankful to my colleagues and students for their valuable suggestions and also drawing my attention towardsminor errors and omissions in the fi rst edition of my book, textbook of histology and a practical guide released in 2007. Rather than reproducing the information found in a histology textbook, a user is shown how to apply this knowledge to interpret cells and tissues as viewed through a microscope. Histological studies on the spleen of large white yorkshire pig sus scrofa article pdf available in journal of entomology and zoology studies 601. Capsule dense connective tissue enclosing the organ trabeculae connective tissue that extends inward from the capsule through which blood vessels enter the pulp white pulp composed of lymphatic tissue. Spleen histology slide labeled the spleen is a fist sized organ located in the left upper quadrant of the abdomen. Each compartment has its own structure, cell population, and functions. Collagen fibers blue are restricted to the capsule.
Histology of spleen 16 images normal spleen histology, image. The microscopic structure of the spleen has been most thoroughly investigated in mice and rats. The spleen has a unique location, embryological development and histological structure that differs significantly from other lymphoid organs. Functions of spleen in health and disease semantic scholar.
On the outer edge, note the presence of a capsule from which short trabeculae containing a trabecular artery and trabecular vein extend into the parenchyma. Special histological features define several important functions of the spleen, such as filtering blood, maintaining immune response balance and. Keywords dogs, clonality, immunophenotype, indolent lymphoma, hyperplasia, ki67 proliferation index, spleen canine splenic nodular lymphoid lesions are primarily com. I have tried to explain the identification points of the spleen. It is attached to the greater curvature of the stomach by the gastrosplenic ligament. Postsplenectomy sequelae are now well recognized, and conservative splenic surgery is widely advocated. These include the white pulp with tcell areas and bfollicles, the nonfiltering lymphoid areas of the red pulp, the border between red and white pulp the perifollicular zone, the red pulp cord tissue and sinuses, and the perivascular rim. Spleen birte steiniger, university of marburg, marburg, germany the spleen is a secondary lymphoid organ present in all vertebrates.
The spleen lies vertically on the left side of the cranial abdomen. Spleen structure and function, splenic blood circulation, immune. It shows how the artery has a lymphoid sheath surrounding the artery, as it enters the spleen, with aggregations of secondary lymphoid tissue. Learn spleen histology with free interactive flashcards. I am very happy to state that i have tried to incorporate almost all of them as. The ratio of splenic weight to body weight remains fairly constant regardless of age and, in rats, is typically around 0. Attached to the greater curvature of the stomach by. Histology slide courtesy of osu college of veterinary medicine.
Normal structure, function, and histology of the spleen mark f. Anatomical and histomorphological study of spleen and. Histopathology of the spleen toxicologic pathology. Like the lymph node, the human spleen is a highly compartimentalized organ. Anatomy and histology of biliary system internet archive. Liver hepar the largest gland of the body intraperitoneal organ functions. These functions are carried out by the 2 main compartments of the spleen, the white pulp including the marginal zone and the red pulp, which.
Pdf histological studies on the spleen of large white. Size of a pinched fist 12cm long, 7cm width weighing 150g. The spleen is the largest lymphoid organ in the body and is interposed within the circulatory system. Also remove heinz bodies or other red blood cell inclusions peripheral blood has howelljolly bodies if no functional spleen is present white pulp. This new edition of jaypees well established colour atlas and practical guide has been enriched by the addition of a large number of new photomicrographs of human tissues. In contrast to the other organs we have seen so far, the spleen is not arranged into cortex and medulla. Jan 21, 2018 in this video, i have tried to narrate the salient features of histology of the spleen. This paper documents spontaneous background and treatmentinduced lesions seen in rodent toxicity and carcinogenicity studies. It examines the correlation between structure and function. This is where the regions of white pulp are found then as the artery loses its sheath and branches to form pencillar arteries, and sinusoids. It is the largest lymphoid organ and thus the largest filter of blood in the human body.
This is a section of the spleen showing the fibrous capsule at the surface and the red and white pulp regions within the organ. May 17, 2020 the spleen is a fist sized organ located in the left upper quadrant of the abdomen. Because sev eral pathologic changes in the spleen have been covered in other chapters, we will not attempt. Aug 17, 2017 an introduction to the histology of the spleen, as presented by the university of rochester pathology it program. Textbook of human histology 6th edition pdf free books pdf epub. The spleen is covered by a dense capsule, and there are connective tissue trabeculae, which provide internal support for the spleen, and carry the blood vessels into the spleen. The red pulp has a normal vascularity and does not appear to be expanded.
Veterinary pathology canine splenic nodular lymphoid lesions. Spleen, red pulp, white pulp, pals, marginal zone, follicles. The two major functional zones of the spleen are the hematogenous red pulp and the lymphoid white pulp periarteriolar sheaths, follicles and marginal zones. With the spleen retracted medially, the phrenicocolic ligament is incised. These include the white pulp with tcell areas and bfollicles, the nonfiltering lymphoid areas of the red pulp, the border between red and white pulp the perifollicular zone, the red pulp cord.
In a sinus seen in crosssection the endothelial cells would extend out of the screen. This diagrammatic representation of the spleen, should help you understand where red and white pulp come from. The spleen has a dense connective tissue capsule, which contains trabeculae running into the interior of the spleen forming incomplete compartments as in the thymus. Textbook of human histology 6th edition pdf free download. The spleen is considered the draining site for compounds that are administered intravenously us fda, 2001. Sh practical lymphatic structure and organs embryology. For enhanced histopathology, these splenic compartments should be. Learn histology blood lymph spleen with free interactive flashcards. Spleen red pulp the red pulp is mainly filled with venous sinuses, which contain red blood cells and occasionally white blood cells. The spleen is an encapsulated organ that filters blood and immunologically monitors blood. Current diagnostic pathology 1997 4, 100105 1997 pearson professional ltd histology of the spleen. Pathologic spleen sections demonstrated benign splenic parenchyma overlying a fibrous cyst wall, the inner lining of which contained no epithelial membrane. The two major functional zones of the spleen are the hematogenous red pulp and the lymphoid white pulp. The gross appearance and size of the spleen are variable, depending on the species and the degree of distension.
Forms sheaths of lymphoid cells around arteries periarteriolar lymphatic sheath, composed of t cells and lymphoid follicles b cells with surrounding mantle zone proliferating b cells and. Spleen, dog labels histology slide this is a histology slide of a dog spleen. Spleen stained with azan to distinguish the stroma or connective tissue components from the parenchyma. Below are the 28 histology slides identification points of 1st year mbbs. For enhanced histopathology, these splenic compartments should be evaluated separately for changes in size and cellularity, and descriptive rather than interpretive terminology should be. Histology guide solves this problem by recreating the look and feel of a microscope in an intuitive, browserbased interface. To ensure usersafety and faster downloads, we have uploaded this.
The same basic the spleen is covered by a thin fibrous capsule with elements as in higher vertebrates are typically present. The spleen is delivered to the midline by means of blunt and sharp dissection of the areolar plane between the kidney and the pancreas. Cronic lymphocytic leukemiais a bcell leukemia that is characterized by the progressive accumulation of relatively mature, but functionallyincompetent, lymphocytes. The spleen is enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae. The spleen has multiple functions in the human body. Introduction spleen alone plays an essential role in antigen the spleen is usually a solitary, dark red organ in the organ 2. The nodules of white pulp are wellspaced and have germinal center formation. Choose from 332 different sets of histology blood lymph spleen flashcards on quizlet. It appears basophilic due to the large number of nuclei. Liver, pancreas, spleen allatorvostudomanyi egyetem. Full text get a printable copy pdf file of the complete article 968k, or click on a page image below to browse page by page.
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